New York - Mar 1st, 2018 - Creative Bioarray, as an innovative biotechnology company whose mission focuses on developing unique technologies that provide global scientists with high-quality products and satisfactory services, offering professional cell line authentication - STR profiling to detect laboratory errors such as misidentification and cross-contamination of lines.
Thousands of studies could be flawed due to contaminated cells. For a long time, researchers have known the problem of misidentification of cells (known as cell lines) that grow in the lab due to contamination. The first major report on this issue was published in 1968. For example, some research papers report the results of "lung cancer cells", which are liver cancer cells.
What are cell lines, how are they used?
Researchers often study the cells they collect from normal or diseased human or animal tissue and grow in the lab. They research this to learn more about how cells work in the human body. Also, researchers utilize these cells to understand the role of potential new drugs, for example, whether they kill tumor cells rather than normal cells.
When cells grow in the lab, they naturally die after some time. However, if they grow under special conditions, they can continue to grow and divide to make new cells. At this stage, these cells are called "cell lines."
Cells can also be frozen, then resurrected again and grown in the lab again. This allows cells to be distributed and shared with other researchers.
Researchers know exactly what type of cells they are working on, so every cell line has a unique name and a researcher's record of the features.
However, sometimes cell lines are misidentified, possibly because they are contaminated by other cells in the laboratory. If researchers are not aware, they may work with "wrong" cells and share their results (and potentially affected cell lines) with other researchers.
The Impact of Cell contamination
The first concern about contaminated cell line was raised more than half a century ago. Until now, this issue remains a pressing one for researchers.
Although some articles referring to "contaminated" research may point to misidentification as such, there is concern that a large body of research that may build on the false grounds remains a concern.
Contaminated cell lines have a significant impact, the results of these studies may lead the researchers to incorrect conclusions and conduct more studies based on these results. As a result, these studies may waste valuable research time and money.
On the other hand, researchers realized that not all the papers they identified found a serious mistake. In some cases, the exact source or characteristics of the cell line may not actually affect the outcome of the experiment.
What measures can be taken to solve cell contamination?
At present, ICLAC has released guidelines designed to minimize the misidentification. Researchers may have already checked to make sure that their cell line is what they need. They also take steps to ensure they will not contaminate their cells.
And, researchers also put forward some suggestions to improve the status quo:
• The report found that papers incorrectly identified cell lines need to be clearly labeled so that other researchers can easily find them.
• Make sure researchers will not ‘misslead’ research in their own publication
• Those who are trying to clean up the contamination should write down the issue of contamination, sharing via social media and general media coverage to highlight issues and stimulate more research reviews
• In cases where wrongly identified cell lines produce erroneous conclusions, the documents should be formally withdrawn
• Get professional cell line authentication service while process researching.
About Cell Line Authentication service offered by Creative Bioarray:
Creative Bioarray provides the world’s most comprehensive list of cells and has realized that animal and human primary cells, tumor cell lines, continuous (immortalized) cell lines, and tissues are very important to the biopharmaceutical industry and to biomedical research as reagents, therapeutic modalities, and as proxy materials.
Creative Bioarray STR profiling is critical for verifying the identity of human cell lines, ensuring uniqueness of the cell line and detecting laboratory errors such as misidentification and cross-contamination of lines. The sensitivity and high power of discrimination make our STR analysis an ideal choice for the various types of cell authentication.
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Company Name: Creative Bioarray
Contact Person: Chelsea Clark
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Phone: 1-631-619-7922
Address:45-1 Ramsey Road Shirley
City: Long Island City
State: New York
Country: United States
Website: http://www.creative-bioarray.com
