Shirley, NY - Dec 30, 2025 - Building from a strong foundation of innovation, expertise, and reliability, Creative Biogene has gradually evolved from a manufacturer to a leading gene editing solutions provider. As a leading life sciences and diagnostics company, Creative Biogene continues to invest in its operations and DNA synthesis technologies. Recently, in response to the growing demands of the biotechnology sector, Creative Biogene proudly announces the launch of its pegRNA Synthesis Service, designed to support cutting-edge prime gene editing applications.
PegRNA synthesis service is a significant advancement in precision gene editing, enabling researchers to undertake complex genetic modifications with increased accuracy and reduced off-target effects. Prime Editing represents the forefront of gene editing technology, distinguishing itself from conventional CRISPR/Cas9 methods by eliminating the need for DNA double-strand breaks (DSBs) and reducing the incidence of unintended genetic alterations. At the core of this technology lies pegRNA (prime editing guide RNA), which functions in both the targeting and editing process of genetic material. Creative Biogene’s pegRNA synthesis service is tailored to meet the requirements for research, preclinical studies, and GMP-grade projects, offering a seamless solution for researchers pursuing high-precision gene modification.
The pegRNA synthesized through Creative Biogene leverages a sophisticated long RNA synthesis platform. This platform accommodates diverse lengths, ranging from standard 120 nt to up to 270 nt, ensuring flexibility for various experimental needs, including PE2, PE3, and ePegRNA requisites. Furthermore, the service maintains a robust quality assurance process, ensuring molecular weight precision and high-purity options through advanced purification techniques.
Prime Editing and pegRNA offer several notable advantages, including the elimination of double-strand breaks, which significantly reduces the risks of insertions, deletions, and chromosomal rearrangements. This innovative approach supports a wide range of genetic modifications, including base substitutions, fragment insertions, and deletions, showcasing its broad editing capabilities. Additionally, Prime Editing reduces off-target effects, resulting in higher specificity and fewer unintended by-products compared to traditional gene editing methods. Its adaptability further distinguishes it, making it particularly effective for targeting challenging genomic loci that often resist homology-directed repair (HDR).
Marcia Brady, a leading researcher at Creative Biogene, emphasized the transformative potential of this service, stating, “The pegRNA Synthesis Service embodies the cutting-edge of gene editing technology. It allows researchers to execute precise modifications with unprecedented accuracy, opening new avenues for innovation in genetic research and therapeutic applications.”
The dedicated pegRNA Synthesis Platform is designed to ensure that high-quality, reproducible, and functional pegRNAs are consistently produced. Creative Biogene adheres to a strict multi-layer quality control system throughout the production process, from raw material selection to final product testing. This includes rigorous standards in manufacturing, such as operating within ISO Class 7/8 cleanrooms, to maintain an RNase-free environment, alongside automated synthesis systems that minimize human error.
In addition to pegRNA synthesis, the suite of services includes complementary products such as Cas9-RT mRNA, nick sgRNA, and HDR templates, providing researchers with a comprehensive toolkit to facilitate their Prime Editing endeavors. Quality assurance is further enhanced with regulatory documentation support for researchers requiring evidence for IND/CTA submissions.
About Creative Biogene
As the landscape of gene editing evolves, the introduction of the pegRNA Synthesis Service positions Creative Biogene as a pivotal player in advancing precision gene editing technologies. This service ensures that researchers have access to high-quality components essential for success in innovative genetic research. Our scientists work shoulder-to-shoulder with scientific and global health partners to enable genomics breakthroughs at scale.
Media Contact
Company Name: Creative Biogene
Contact Person: Marcia Brady
Email:Send Email
Phone: 6313868241
Address:Shirley
City: New York
State: New York 11967
Country: United States
Website: https://www.creative-biogene.com/
