DelveInsight's “Sepsis Drugs Market Insights, Epidemiology and Market Forecast – 2034” report delivers an in-depth understanding of Sepsis, historical and forecasted epidemiology as well as the Sepsis market trends in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.
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Key Takeaways from the Sepsis Market Report
- In December 2024: Basilea Pharmaceuticals- This study will evaluate the safety, pharmacokinetics and efficacy of ceftobiprole in term and pre-term newborn babies and infants up to 3 months of age with late-onset sepsis (LOS). Ceftobiprole is an antibiotic which belongs to a group of medicines called 'cephalosporin antibiotics'. It is approved for its use to treat adults and children with pneumonia in many European and non-European countries.
- In December 2024:- Novartis Pharmaceuticals- The purpose of this Ph2b study is to characterize the dose-response relationship and to evaluate the safety and efficacy of three different single doses of TIN816 in hospitalized adult participants in an intensive care setting with a diagnosis of sepsis-associated acute kidney injury (SA-AKI).
- Among 7MM, the United States accounted for the maximum share of the Sepsis population with above 55% in 2023.
- In EU4 and the UK, Germany accounted for the highest number of incident cases in 2023.
- As per analysis, it is notable that in the 7MM, the majority of patient pool were males as compared to females whereas in the US female population dominated the Sepsis incident pool..
- According to Delveinsight, approximately 57% of all cases were sepsis without organ dysfunction followed by septic shock (24%) and severe sepsis (18%) in the United States in 2023. These cases are expected to increase during the forecast period (2024-2034).
- As per the analysis, lung infection, UTI infection, gut infection, and skin infection are the leading four infection sites in patients with sepsis, accounting for approximately 43%, 30%, 13%, and 13% respectively of all sites of infection.
- The leading Sepsis Companies such as La Jolla Pharmaceuticals, Par Pharmaceutical, Ono Pharmaceutical, Vivacelle Bio, Inotrem, Enlivex Therapeutics, Adrenomed, Shionogi, Asahi Kasei Pharma Corp., AM-Pharma, ABIONYX Pharma, Revimmune, Baxter Healthcare Corporation, BioMarck Pharmaceuticals, and others.
- Promising Sepsis Pipeline Therapies such as Alirocumab, Imipenem, Cilastatin and Relebactam, Cefiderocol, SBI-101, Ceftobiprole medocaril, VBI-S, and others.
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Sepsis Epidemiology Segmentation in the 7MM
- Total Sepsis Incident cases
- Sepsis Gender-specific Incident cases
- Sepsis Severity-specific Incident Cases
- Sepsis Origin-specific Incident cases
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Sepsis Marketed Drugs
- GIAPREZA (angiotensin II): La Jolla Pharmaceuticals/Innoviva Specialty Therapeutics
GIAPREZA (angiotensin II) (La Jolla Pharmaceuticals/Innoviva Specialty Therapeutics) injection is approved by the US FDA in December 2017 as a vasoconstrictor to increase blood pressure in adults with septic or other distributive shocks. The drug is also approved by the European Commission in 2019 to treat refractory hypotension in adults with septic or other distributive shocks who remain hypotensive despite adequate volume restitution and application of catecholamines and other available vasopressor therapies. The drug mimics the body’s endogenous angiotensin II peptide, which is central to the renin–angiotensin–aldosterone system, which regulates blood pressure.
- Onoact Injection (Landiolol hydrochloride): Ono Pharmaceuticals
Onoact is a short-acting β1 blocker that selectively blocks β1 receptors mainly found in the heart. It is for emergency treatment of intra-operative or post-operative tachyarrhythmia (atrial fibrillation, atrial flutter, sinus tachycardia) and treatment of tachyarrhythmia in left ventricular dysfunction (atrial fibrillation, atrial flutter). In June 2022, Onoact received approval for intravenous infusion 50mg/150mg, for the additional indication of tachyarrhythmia (atrial fibrillation, atrial flutter, and sinus tachycardia) associated with sepsis for a partial change in the approved items of the manufacturing and marketing approval in Japan.
Sepsis Emerging Drugs
- VBI-S: Vivacelle Bio
Vivacelle Bio’s lead candidate, VBI-S is made of small particles of specific lipid called micelles and liposomes to treat hypotension. VBI-S is an intravenously injectable fluid comprised of phospholipid nanoparticles that were specifically designed to shift the biophysical properties of the ’body’s fluid volume in hypovolemic shock, due to sepsis, from non-survival to survival. In July 2019, the company announced US FDA clearance to enroll patients into a Phase IIa clinical trial of VBI-S to elevate blood pressure in subjects who have shock due to sepsis, later met 100% endpoints in Phase II. The therapy is currently under Phase III clinical evaluation to treat hypovolemia due to sepsis/septic shock.
- Nangibotide: Inotrem
Inotrem’s Nangibotide is a synthetic peptide and first-in-class TREM-1 inhibitor. Nangibotide blocks the TREM-1-mediated immune dysregulations in sterile or infectious acute inflammatory syndromes. The drug restores a balanced inflammatory response and improves outcomes, particularly in those patients with high levels of TREM-1 pathway activation. The drug is currently under Phase II for the treatment of septic shock. This lead candidate has been granted EMA’s PRIority MEdicines (PRIME) scheme, and was also granted Fast-track status by the FDA for septic shock.
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Sepsis Market Outlook
Sepsis is a complex disease, which not only involves a wide array of causative agents but also results in different individual immune responses, causing various single or multiple organ dysfunction. Treatment for sepsis varies, depending on the site and the cause of the initial infection, the organs affected and the extent of any damage. Sepsis should be treated as a medical emergency and treated as quickly and efficiently as possible as soon as it has been identified.
Sepsis Drugs Market
The Sepsis Therapeutics Market in the 7MM is anticipated to grow significantly between the forecasted period [2024-2034], driven by factors such as increasing Sepsis Incidence rates, technological advancements, enhanced funding for drug development, heightened public awareness, and expanding research endeavors. The expected launch of emerging therapies, combined with the rise in Sepsis cases, is poised to fuel market expansion throughout the forecast period. The promising pipeline for Sepsis presents a hopeful outlook for improved treatment modalities in the years ahead.
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Scope of the Sepsis Market Report
- Coverage- 7MM
- Study Period- 2020-2034
- Sepsis Companies- La Jolla Pharmaceuticals, Par Pharmaceutical, Ono Pharmaceutical, Vivacelle Bio, Inotrem, Enlivex Therapeutics, Adrenomed, Shionogi, Asahi Kasei Pharma Corp., AM-Pharma, ABIONYX Pharma, Revimmune, Baxter Healthcare Corporation, BioMarck Pharmaceuticals, and others.
- Sepsis Pipeline Therapies- Alirocumab, Imipenem, Cilastatin and Relebactam, Cefiderocol, SBI-101, Ceftobiprole medocaril, VBI-S, and others.
- Sepsis Therapeutic Assessment: Sepsis current marketed and Sepsis emerging therapies
- Sepsis Market Dynamics: Sepsis market drivers and Sepsis market barriers
- Sepsis Unmet Needs, KOL’s views, Analyst’s views, Sepsis Market Access and Reimbursement
Table of Content
1 Key Insights
2 Report Introduction
3 Executive Summary
4 Key Events
5 Epidemiology and Market Forecast Methodology
6 Sepsis Market Overview at a Glance
7 Sepsis: Disease Background and Overview
8 Treatment and Medical Management
9 Epidemiology and Patient Population of Sepsis
10 Patient Journey
11 Marketed Drugs
12 Key Cross Competition
14 Sepsis: Seven Major Market Analysis
15 KOL Views
16 SWOT Analysis
17 Unmet Needs
18 Market Access and Reimbursement
19 Appendix
20 DelveInsight Capabilities
21 Disclaimer
22 About DelveInsight
About Us
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