New York, US - Feb 27, 2019 - Creative Biolabs, a leader in recombinant antibody discovery and manufacturing, specializes in offering the optimal major histocompatibility complex (MHC) tetramer service to its customers around the globe. With the advance of medical science, MHC tetramers are expected to play a more significant role in the treatment of malignant diseases.
As an immunological reagent, the MHC tetramer consists of four monomeric molecules formed by MHC and antigenic peptides. Labeled with fluorescence molecules, the agent serves as an important tool in the quantitation of the antigen-specific T cell response and the identification of T cell epitopes. The MHC tetramer enjoys unique advantages, and it has been widely used in the research about tumors and viral diseases.
“Since the T cell receptor has low affinity to MHC antigen peptide complex, the resulting recombinant complex is unsuitable for the detection of antigen-specific T cells. In 1996, the MHC tetramer assay technology was developed to mark the target T cells which then was analyzed by means of flow cytometry. Soon, this technology caught on as a quick and easy qualitative and quantitative analysis method for detecting antigen specific T cells. Compared with other T cell detection methods, MHC tetramers has high sensitivity, high specificity, simple quantitative analysis and high reproducibility,” a scientist from Creative Biolabs said.
Nowadays, the MHC Tetramer has been made use of as a promising immunotherapy for breast cancer, melanoma, colon cancer, lung cancer, cervical cancer, hepatitis B and influenza, etc. In the studies about tumors, infections and autoimmune diseases, the MHC Tetramer gains increasing significance in research about cell sorting, antigen epitope screening, virus escape, cellular therapy and MHC immune functions. In general, it has approximately five strengths.
“First, it can accurately and effectively monitor the number of antigen-specific T cells in patients. Second, it recognizes specific antigens. Third, in the development of vaccines, it allows the detection of antigen-specific T cells in unvaccinated or vaccinated patients. Fourth, the MHC tetramer makes it possible for researchers to obtain associated data. Through the natural induction or stimulation of cancer vaccines, the immune response of individuals to specific tumor antigens can be reflected. Fifth, it can be used to assess the immunotherapy effect of patients with hepatitis B,” the same scientist from Creative Biolabs replied.
As an important immune agent, the MHC tetramer constitutes a key component in the production of antibody products. Furthermore, the relevant technology is also maturating and expected to be play more roles in disease treatment when combined with other technologies. In the coming future, more excellent MHC tetramer products will be produced to fulfill the increasingly diverse market demands.
About Creative Biolabs
As a leader in recombinant antibody discovery and manufacturing, Creative Biolabs is committed to providing its global customers with the most comprehensive list of recombinant antibody products and extensive service portfolio at the most competitive price. Its products range from antibody/peptide libraries, biosimilar cell lines, chimeric antigen receptor products, antibody-drug conjugates to engineered antibodies. It also provides a variety of custom antibody discovery and engineering services.
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Company Name: Creative Biolabs
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Website: www.creativebiolabs.net/
