DelveInsight’s “KRAS Inhibitors Market Insights, Epidemiology, and Market Forecast-2034″ report offers an in-depth understanding of the KRAS Inhibitors, historical and forecasted epidemiology as well as the KRAS Inhibitors market trends in the United States, EU4 (Germany, Spain, Italy, France) the United Kingdom and Japan.
To Know in detail about the KRAS Inhibitors market outlook, drug uptake, treatment scenario and epidemiology trends, Click here; KRAS Inhibitors Market Forecast
Some of the key facts of the KRAS Inhibitors Market Report:
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The KRAS Inhibitors market size is anticipated to grow with a significant CAGR during the study period (2020-2034)
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In February 2024, Bristol Myers Squibb reported that the US FDA has granted priority review status to the supplemental New Drug Application (sNDA) for KRAZATI in combination with cetuximab for the treatment of KRASG12C-mutated locally advanced or metastatic colorectal cancer (CRC). The FDA has set a Prescription Drug User Fee Act (PDUFA) goal date of June 21, 2024.
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In January 2024, The European Commission provided conditional approval for KRAZATI to treat advanced non-small cell lung cancer (NSCLC) with KRASG12C mutation, specifically for patients who have experienced disease progression after receiving at least one previous systemic therapy.
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As per NICE (2022), the KRAS oncogene stands out as the frequently mutated gene in lung cancer. Specifically, the KRAS G12C mutation prevails as the most common, found in approximately 12% of non-small cell lung cancer (NSCLC) tumors in the UK.
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According to research published in the American Society of Clinical Oncology (ASCO) by Salem et al. (2022), the most common KRAS variants among all subtypes were G12D (41.8%), G12V (31.6%), G12C (1.8%), G13D (0.4%), and G12R (161%). Notably, KRASG12D was predominantly found in patients diagnosed with pancreatic cancer.
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In the chosen cancer types, Colorectal Cancer has the highest number of KRAS mutant cases, with Pancreatic Cancer and NSCLC following closely. According to the analysis, in the seven major markets (7MM), there were an estimated 216,000 cases of KRAS mutant colorectal cancer in 2023.
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In December 2022, For adult patients with KRASG12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC), as determined by an FDA-approved test, and who have had at least one prior systemic therapy, the FDA has given accelerated approval for KRAZATI (adagrasib), a targeted treatment option.In May 2022, Mirati filed a Marketing Authorization Application (MAA) with the EU.
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Key KRAS Inhibitors Companies: Novartis, Verastem Oncology, Boehringer Ingelheim, Roche, Eli Lilly, Revolution Medicines, and others
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Key KRAS Inhibitors Therapies: JDQ443, Avutometinib, BI 1701963, GDC-6036, LY353798, RMC-4630, and others
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The KRAS Inhibitors market is expected to surge due to the disease's increasing prevalence and awareness during the forecast period. Furthermore, launching various multiple-stage KRAS Inhibitors pipeline products will significantly revolutionize the KRAS Inhibitors market dynamics.
KRAS Inhibitors Overview
KRAS inhibitors are a class of drugs designed to target and block the activity of the KRAS protein, which plays a key role in cell signaling pathways that regulate cell growth and division. KRAS (Kirsten rat sarcoma viral oncogene homolog) is a type of oncogene, meaning it has the potential to cause normal cells to become cancerous when mutated or overactive.
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KRAS Inhibitors Epidemiology
The epidemiology section provides insights into the historical, current, and forecasted epidemiology trends in the seven major countries (7MM) from 2020 to 2034. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. The epidemiology section also provides a detailed analysis of the diagnosed patient pool and future trends.
KRAS Inhibitors Epidemiology Segmentation:
The KRAS Inhibitors market report proffers epidemiological analysis for the study period 2020–2034 in the 7MM segmented into:
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Total Prevalence of KRAS Inhibitors
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Prevalent Cases of KRAS Inhibitors by severity
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Gender-specific Prevalence of KRAS Inhibitors
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Diagnosed Cases of Episodic and Chronic KRAS Inhibitors
Download the report to understand which factors are driving KRAS Inhibitors epidemiology trends @ KRAS Inhibitors Epidemiology Forecast
KRAS Inhibitors Drugs Uptake and Pipeline Development Activities
The drugs uptake section focuses on the rate of uptake of the potential drugs recently launched in the KRAS Inhibitors market or expected to get launched during the study period. The analysis covers KRAS Inhibitors market uptake by drugs, patient uptake by therapies, and sales of each drug.
Moreover, the therapeutics assessment section helps understand the drugs with the most rapid uptake and the reasons behind the maximal use of the drugs. Additionally, it compares the drugs based on market share.
The report also covers the KRAS Inhibitors Pipeline Development Activities. It provides valuable insights about different therapeutic candidates in various stages and the key companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.
KRAS Inhibitors Therapies and Key Companies
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JDQ443: Novartis
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Avutometinib: Verastem Oncology
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BI 1701963: Boehringer Ingelheim
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GDC-6036: Roche
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LY353798: Eli Lilly
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RMC-4630: Revolution Medicines
Discover more about therapies set to grab major KRAS Inhibitors market share @ KRAS Inhibitors Treatment Market
KRAS Inhibitors Market Strengths
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Combining KRAS-targeted therapies with other treatment modalities, such as immunotherapies or traditional chemotherapy, holds promise for improving treatment outcomes. The potential for combination therapies creates additional market opportunities and enhances the overall market strength of KRAS mutations.
KRAS Inhibitors Market Opportunities
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To enhance the effectiveness of KRASG12C inhibitors in NSCLC, it is crucial to integrate them into the first-line standard of care(SOC). Nevertheless, the currently available agents have encountered difficulties due to toxic side effects when combined with anti-PD-(L)1 therapy.
Scope of the KRAS Inhibitors Market Report
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Study Period: 2020–2034
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Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan]
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Key KRAS Inhibitors Companies: Novartis, Verastem Oncology, Boehringer Ingelheim, Roche, Eli Lilly, Revolution Medicines, and others
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Key KRAS Inhibitors Therapies: JDQ443, Avutometinib, BI 1701963, GDC-6036, LY353798, RMC-4630, and others
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KRAS Inhibitors Therapeutic Assessment: KRAS Inhibitors current marketed and KRAS Inhibitors emerging therapies
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KRAS Inhibitors Market Dynamics: KRAS Inhibitors market drivers and KRAS Inhibitors market barriers
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Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter’s five forces, BCG Matrix, Market entry strategies
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KRAS Inhibitors Unmet Needs, KOL’s views, Analyst’s views, KRAS Inhibitors Market Access and Reimbursement
To know more about KRAS Inhibitors companies working in the treatment market, visit @ KRAS Inhibitors Clinical Trials and Therapeutic Assessment
Table of Contents
1. KRAS Inhibitors Market Report Introduction
2. Executive Summary for KRAS Inhibitors
3. SWOT analysis of KRAS Inhibitors
4. KRAS Inhibitors Patient Share (%) Overview at a Glance
5. KRAS Inhibitors Market Overview at a Glance
6. KRAS Inhibitors Disease Background and Overview
7. KRAS Inhibitors Epidemiology and Patient Population
8. Country-Specific Patient Population of KRAS Inhibitors
9. KRAS Inhibitors Current Treatment and Medical Practices
10. KRAS Inhibitors Unmet Needs
11. KRAS Inhibitors Emerging Therapies
12. KRAS Inhibitors Market Outlook
13. Country-Wise KRAS Inhibitors Market Analysis (2020–2034)
14. KRAS Inhibitors Market Access and Reimbursement of Therapies
15. KRAS Inhibitors Market Drivers
16. KRAS Inhibitors Market Barriers
17. KRAS Inhibitors Appendix
18. KRAS Inhibitors Report Methodology
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight
About DelveInsight
DelveInsight is a leading Healthcare Business Consultant, and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.
It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate the business growth and overcome challenges with a practical approach.
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