New York, US - Oct 1, 2018 - Recently, Creative Biolabs, the leading service provider in the field of antibody discovery and immunotherapy for years, launched professional bispecific T-cell receptor (TCR) development services with superior quality in a de novo manner.
Bispecific TCR refers to a molecule that can regulate the body’s immune system by redirecting and promote the T-cell response towards cancer cells with specific tumor targets, in which the TCR is a molecule existed on the surface of T cells, or T lymphocytes that recognizes fragments of antigen to provide peptides bound to major histocompatibility complex (MHC) molecules.
There are two domains of novel bispecific TCRfrom Creative Biolabs, including an affinity-maturated and highly selective TCR domain that can recognize and bind to a tumor-specific peptide target presented in the context of human lymphocyte antigen (HLA) class I receptor, and a T-cell recruiting antibody domain directed against CD3 or other immuno-modulating T-cell surface proteins, which are characterized by the ability of T cell activation to attack the tumor regardless of the T cells’ intrinsic specificity. After being administrated to the patients, these bispecific TCRs will selectively bind to the surface of targeted tumor cells and then recruit and activate T cells via CD3 binding initiates tumor killing.
Ph.D. level scientists and skillful technicians occupied in immunotherapy filed for decades with great reputation and experience in Creative Biolabs are capable of providing high-quality bispecific TCRs with low off-target toxicity and superior quality. The affinity optimization assays are also fully prepared to offer a perfect experiment result during the bispecific TCR development.
About Creative Biolabs
As a global company, Creative Biolabs has more than 200 talented and well-trained scientists located in different continents working closely with partners from the entire world to develop and produce medicines of tomorrow. Specifically, we are the established leading expert in TCR and chimeric antigen receptor (CAR)-T&NK cell immune therapy development, as we offer the one-stop custom services that cover the entire new drug development pipeline. Additionally, we also offer an exclusive line of ready-to-use TCR and CAR T&NK cell construction products, such as virus packaging, purification, expansion and titer determination kits. Furthermore, we have built up a unique unparalleled CAR construction and production platform for all four CAR generations.
Media Contact
Company Name: Creative Biolabs
Contact Person: Bella Smith
Email:Send Email
Phone: 1-631-619-7922
Address:45-1 Ramsey Road
City: Shirley
State: New York
Country: United States
Website: https://www.creative-biolabs.com/car-t
