New York - May 31st, 2018 - Creative Bioarray, as an innovative biotechnology company, focusing on offering high quality products and professional services to accelerate the investigation of life science, in which, Creative Bioarray has developed a variety of in vitro genotoxicity tests In order to identify genotoxic chemicals early in the drug development process, which include but not limited to: chromosomal aberration test, gene mutation test, and Ames test.
The chromosomal aberration test with cultured mammalian cells is one of the sensitive methods for predicting environmental mutagens and/or carcinogens, which is also a supplemental test for the Salmonella/microsome test (Ames test). Most chemical substances cause chromatid aberrations, some compounds induce only destructive aberrations at relatively high dose levels, while others induce more exchange-type aberrations at relatively lower dose levels.
Over the past 20 years, there have been considerable evolutionary changes in the in vitro detection of chromosomal aberrations (CA). Processing and sampling time has always been the focus of attention because we are trying to develop a program to detect weak genotoxins. Different approaches have emerged in different parts of the world, leading to the need for coordination. Meanwhile, we are increasingly questioning the conditions under which germs respond positively, and several situations have been described in which the fragmentation response is considered not biologically relevant. Therefore, it is correct to carefully consider whether the type of damage in the CA test is related to human health.
For the methods which can be applied for chromosomal aberration, currently, Creative Bioarray follows OECD guideline 4731 to conduct an in vitro mammalian chromosome aberration test. The proliferating mammalian cell cultures are exposed to test chemicals with and without a metabolically-activated exogenous source. After the test articles are exposed for an appropriate period of time, the cells are treated with mid-term stagnant substances and harvested. Chromosomal diffusion slides are then prepared and stained. The chromosomal aberrations of metaphase cells were analyzed under a microscope. Each study included negative vector control and positive controls.
At present, the available types of genetic testing include:
• Newborn screening, which can be used to identify genetic diseases that can be treated early in life after birth
• Diagnostic testing, which can be performed before birth or at any time during a person's life, but not for all genes or all genetic disorders, applying to identify or rule out specific genetic or chromosomal disorders
• Prenatal testing for the detection of prenatal fetal gene or chromosome changes
• Carrier test, being used to identify people carrying a copy of a gene mutation
And Creative Bioarray can provide in vitro mammalian cell gene mutation test 3 according to GLP principle3.
About Creative Bioarray
Creative Bioarray, who are addicted to offering global customers with cutting-edge products and high quality services, including primary cells, tumor cells, stem cells, and biosample services and histology services etc. Besides, we also provide custom services per different requirements from each customer.
Media Contact
Company Name: Creative Bioarray
Contact Person: Chelsea Clark
Email:Send Email
Phone: 1-631-619-7922
Address:45-1 Ramsey Road Shirley
City: Long Island City
State: New York
Country: United States
Website: http://www.creative-bioarray.com
