As Giant Cell Arteritis (GCA) becomes increasingly prevalent worldwide and contributes to comorbidities such as diabetes, cardiovascular disease, and certain cancers, the demand for safer and more effective treatments continues to grow. DelveInsight reports that more than six pharmaceutical and biotech companies are actively advancing over six therapeutic candidates targeting GCA. These candidates are in various stages of preclinical and clinical development, reflecting significant innovation and dedication to addressing this critical public health challenge.
DelveInsight’s “Giant Cell Arteritis Pipeline Insight 2025” provides a comprehensive analysis of the current R&D landscape. The report examines clinical trial progress, emerging therapies, mechanisms of action, competitive positioning, and strategic initiatives by leading companies. It is a valuable resource for researchers, healthcare investors, and decision-makers seeking insights into the evolving GCA therapeutics market and the innovations shaping its future.
Explore the Cutting-Edge Landscape of Giant Cell Arteritis Drug Development
Key Takeaways from the Giant Cell Arteritis Pipeline Report
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DelveInsight’s Giant Cell Arteritis (GCA) pipeline report highlights a dynamic landscape, with over six active companies developing more than six therapeutic candidates for GCA treatment.
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In July 2025, Novartis’ Cosentyx (secukinumab) did not meet its primary endpoint in the Phase III GCAptAIN trial, failing to show a significant improvement in sustained remission at 52 weeks compared to placebo. Although there were reductions in steroid use, these differences were not statistically significant.
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In contrast, in April 2025, AbbVie’s Rinvoq (upadacitinib) became the first oral JAK inhibitor approved by the FDA for adult GCA patients. Approval was based on the Phase III SELECT‑GCA trial, where 46.4% of patients receiving 15 mg daily with a steroid taper achieved sustained remission between weeks 12 and 52, compared to 29% in the placebo group (p = 0.002).
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Key companies—including Novartis, AbbVie, XOMA, Kiniksa, Eli Lilly, Janssen Biotech, Dr. Reddy’s Laboratories, and others—are actively developing new therapies to enhance the GCA treatment landscape. Promising pipeline candidates in various stages of development include Secukinumab, Upadacitinib, and additional therapies.
Giant Cell Arteritis Overview:
Giant cell arteritis (GCA) is the most common type of vasculitis in individuals over 50, characterized by inflammation of medium and large arteries. This inflammation thickens and damages vessel walls, reducing blood flow. The temporal and other cranial arteries are often affected—a form known as cranial GCA—but the aorta and other large vessels can also be involved, referred to as large-vessel GCA, which may present with distinct symptoms. Without timely diagnosis and treatment, GCA can cause serious complications, including sudden and permanent vision loss.
When cranial arteries are involved, patients may experience unilateral or occipital headaches, jaw pain while chewing (jaw claudication), scalp tenderness, arm discomfort, visual disturbances such as double vision, and noticeable, tender swelling of the temporal artery. Systemic symptoms, more common in large-vessel GCA, can include fever, weight loss, loss of appetite, and polymyalgia. While the exact cause of GCA is unknown, it is believed to result from the immune system attacking the body’s own blood vessels.
GCA is closely associated with polymyalgia rheumatica (PMR): approximately 40–60% of GCA patients also have PMR, and 15–20% of PMR patients may develop GCA. Treatment typically involves corticosteroids to relieve symptoms and prevent recurrence, often combined with immunosuppressive therapies to regulate the immune response.
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Giant Cell Arteritis Pipeline Analysis
The Giant Cell Arteritis pipeline insights report 2025, provides insights into:
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Provides comprehensive insights into key companies developing therapies in the Giant Cell Arteritis Market.
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Categorizes Giant Cell Arteritis therapeutic companies by development stage: early, mid, and late-stage.
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Highlights major companies involved in targeted therapy development, including both active and inactive (paused/discontinued) projects.
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Reviews emerging Giant Cell Arteritis drugs under development based on:
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Stage of development
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Giant Cell Arteritis Route of administration
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Target receptor
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Monotherapy vs. combination therapy
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Giant Cell Arteritis Mechanism of action
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Molecular type
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Offers detailed analysis of:
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Company-to-company and company-academia collaborations
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Giant Cell Arteritis Licensing agreements
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Funding and investment activities supporting future Giant Cell Arteritis market advancement.
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Unlock key insights into emerging Giant Cell Arteritis therapies and market strategies here: https://www.delveinsight.com/report-store/giant-cell-arteritis-pipeline-insight?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr
Giant Cell Arteritis Emerging Drugs
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Secukinumab: Novartis
Secukinumab is a fully human monoclonal antibody (IgG1/κ) that specifically targets interleukin-17A (IL-17A), a key proinflammatory cytokine implicated in chronic immune-mediated inflammatory disorders such as plaque psoriasis. By inhibiting IL-17A, secukinumab helps reduce inflammation associated with these conditions.
The therapy was initially approved in Japan in December 2014, followed by approval from the European Commission on January 15, 2015, and the U.S. FDA on January 21, 2015. Secukinumab is currently approved for plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. It is now undergoing Phase III clinical trials to assess its potential in treating Giant Cell Arteritis (GCA).
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Upadacitinib: AbbVie
Upadacitinib is an oral, selective Janus kinase 1 (JAK1) inhibitor approved for treating several inflammatory disorders, including moderate to severe rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, and severe atopic dermatitis, particularly in patients who have not responded adequately to prior treatments. The FDA approved upadacitinib in August 2019 for multiple indications, including rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, ulcerative colitis, and ankylosing spondylitis, while the European Commission followed with approval in December 2019. Marketed as RINVOQ, it is currently being evaluated in Phase III clinical trials for its potential use in Giant Cell Arteritis (GCA).
Giant Cell Arteritis Pipeline Therapeutic Assessment
Giant Cell Arteritis Assessment by Product Type
• Mono
• Combination
• Mono/Combination
Giant Cell Arteritis By Stage
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
Giant Cell Arteritis Assessment by Route of Administration
• Oral
• Parenteral
• Intravenous
• Subcutaneous
• Topical
Giant Cell Arteritis Assessment by Molecule Type
• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy
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Table of Contents
1. Report Introduction
2. Executive Summary
3. Giant Cell Arteritis Current Treatment Patterns
4. Giant Cell Arteritis - DelveInsight's Analytical Perspective
5. Therapeutic Assessment
6. Giant Cell Arteritis Late-Stage Products (Phase-III)
7. Giant Cell Arteritis Mid-Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Giant Cell Arteritis Discontinued Products
13. Giant Cell Arteritis Product Profiles
14. Giant Cell Arteritis Key Companies
15. Giant Cell Arteritis Key Products
16. Dormant and Discontinued Products
17. Giant Cell Arteritis Unmet Needs
18. Giant Cell Arteritis Future Perspectives
19. Giant Cell Arteritis Analyst Review
20. Appendix
21. Report Methodology
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