“Hypertension Pipeline Insight, 2025" report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the Hypertension Market.
The Hypertension Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details.
Some of the key takeaways from the Hypertension Pipeline Report:
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Companies across the globe are diligently working toward developing novel Hypertension treatment therapies with a considerable amount of success over the years.
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Hypertension companies working in the treatment market are Addpharma Inc., Alnylam Therapeutics, ORPHAI THERAPEUTICS, 35Pharma Inc., Aerovate Therapeutics, Novartis, Keros Therapeutics, Vigonvita Life Sciences, Insmed Incorporated, Chugai Pharmaceutical, Merck Sharp & Dohme, Janssen Pharmaceutical, Actelion, Gossamer Bio, Lung Biotechnology PBC, United Therapeutics, Gilead Science, Acceleron Pharma, Eiger BioPharmaceuticals, AstraZeneca, and others, are developing therapies for the Hypertension treatment
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Emerging Hypertension therapies in the different phases of clinical trials are- AD-209, Zilebesiran, LAM-001, HS135, AV-101, LTP001, KER-012, TPN171H, Treprostinil Palmitil, Satralizumab (Genetical Recombination), Sotatercept, Macitentan, ACT-293987, GB002 (seralutinib), Parenteral Treprostinil, Ralinepag, Selonsertib, Sotatercept, ubenimex, Olaparib, and others are expected to have a significant impact on the Hypertension market in the coming years.
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In September 2025, AllRock Bio Inc., a clinical-stage biotech company developing therapies for cardiopulmonary and fibrotic diseases, announced a $50 million Series A financing round co-led by Versant Ventures and Westlake BioPartners. The funding will support the advancement of its lead candidate, ROC-101—an oral, first-in-class pan-rho-associated protein kinase (ROCK) inhibitor exclusively licensed from Sanofi—into Phase 2 clinical trials. ROC-101 is being developed to treat pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease (ILD-PH), both life-threatening conditions with poor five-year survival rates of 57% and 38%. By targeting inflammatory, proliferative, and fibrotic remodeling driven by both ROCK1 and ROCK2, ROC-101 holds promise to meet a major unmet need in these patient populations.
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In August 2025, Cereno Scientific’s lead candidate, CS1, has been granted FDA Fast Track designation for pulmonary arterial hypertension, acknowledging its promise as a novel and potentially disease-modifying therapy for this rare and severe condition.
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In August 2025, VASTHERA Co., Ltd. announced FDA clearance of its Investigational New Drug (IND) application to begin a Phase 1 trial for VTB-10, a novel candidate for pulmonary arterial hypertension (PAH). Developed via the company’s proprietary Redoxizyme™ platform, VTB-10 is a first-in-class small molecule enzyme (Chemzyme) designed to mimic the function of peroxiredoxin (PRX), which is deficient in PAH lesions. Preclinical data showed that VTB-10 not only reversed abnormal vascular remodeling but also restored healthy endothelial function, offering a dual mechanism of action that sets it apart from current treatment options.
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In March 2025, Merck (NYSE: MRK), also known as MSD outside the U.S. and Canada, has shared initial results from its Phase 3 ZENITH trial evaluating WINREVAIR™ (sotatercept-csrk) versus placebo in adults with pulmonary arterial hypertension (PAH, Group 1 PH), classified as WHO functional class III or IV and at high risk of mortality, despite receiving the maximum tolerated background PAH therapy. With a median follow-up of 10.6 months (range: 0.3–26.1), WINREVAIR significantly reduced the relative risk of major morbidity and mortality events—including all-cause death, lung transplantation, or PAH-related hospitalization (≥24 hours)—by 76% (HR=0.24 [95% CI, 0.13–0.43]; p
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In January 2025, Merck (NYSE: MRK), known as MSD outside the United States and Canada, announced preliminary findings from its Phase 3 ZENITH trial assessing WINREVAIR™ (sotatercept-csrk) against placebo in adults with pulmonary arterial hypertension (PAH, Group 1 PH), specifically those categorized as WHO functional class III or IV and considered at high risk of mortality despite being on optimized background PAH treatment. Over a median follow-up period of 10.6 months (range: 0.3–26.1), WINREVAIR demonstrated a 76% reduction in the relative risk of major morbidity and mortality events—defined as all-cause death, lung transplant, or PAH-related hospitalization lasting 24 hours or more—compared to placebo (HR=0.24 [95% CI, 0.13–0.43]; p
Hypertension Overview
Hypertension, commonly known as high blood pressure, is a chronic medical condition in which the force of blood against the artery walls remains consistently elevated. Over time, this increased pressure can strain the heart and blood vessels, leading to serious health problems such as heart disease, stroke, kidney damage, and vision loss. It is often called a “silent killer” because it may not cause noticeable symptoms until complications arise. Hypertension is typically managed through lifestyle changes—like a healthy diet, regular exercise, and reduced salt intake—and medications to help control blood pressure levels.
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Emerging Hypertension Drugs Under Different Phases of Clinical Development Include:
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AD-209: Addpharma Inc.
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Zilebesiran: Alnylam Therapeutics
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LAM-001: ORPHAI THERAPEUTICS
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HS135: 35Pharma Inc.
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TYVASO/TYVASO DPI/TREPROST Inhalation Solution (treprostinil): United Therapeutics/Mochida Pharmaceutical
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OPSYNVI/YUVANCI (macitentan and tadalafil): Johnson & Johnson
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WINREVAIR (sotatercept): Merck
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UPTRAVI (selexipag): Johnson & Johnson/ Nippon Shinyaku
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AV-101: Aerovate Therapeutics
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LTP001: Novartis
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KER-012: Keros Therapeutics
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TPN171H: Vigonvita Life Sciences
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Treprostinil Palmitil: Insmed Incorporated
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Satralizumab (Genetical Recombination): Chugai Pharmaceutical
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Sotatercept: Merck Sharp & Dohme
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Macitentan: Janssen Pharmaceutical
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ACT-293987: Actelion
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GB002 (seralutinib): Gossamer Bio
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Parenteral Treprostinil: Lung Biotechnology PBC
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Ralinepag: United Therapeutics
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Selonsertib: Gilead Sciences
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Sotatercept: Acceleron Pharma
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ubenimex: Eiger BioPharmaceuticals
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Olaparib: AstraZeneca
Hypertension Route of Administration
Hypertension pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as
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Oral
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Parenteral
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Intravitreal
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Subretinal
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Topical
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Molecule Type
Hypertension Molecule Type
Hypertension Products have been categorized under various Molecule types, such as
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Monoclonal Antibody
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Peptides
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Polymer
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Small molecule
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Gene therapy
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Product Type
Hypertension Pipeline Therapeutics Assessment
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Hypertension Assessment by Product Type
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Hypertension By Stage and Product Type
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Hypertension Assessment by Route of Administration
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Hypertension By Stage and Route of Administration
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Hypertension Assessment by Molecule Type
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Hypertension by Stage and Molecule Type
DelveInsight's Hypertension Report covers around 100+ products under different phases of clinical development like
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Late-stage products (Phase III)
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Mid-stage products (Phase II)
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Early-stage product (Phase I)
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Pre-clinical and Discovery stage candidates
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Discontinued & Inactive candidates
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Route of Administration
Further Hypertension product details are provided in the report. Download the Hypertension pipeline report to learn more about the emerging Hypertension therapies
Some of the key companies in the Hypertension Therapeutics Market include:
Key companies developing therapies for Hypertension are - VasThera Co Ltd, Altavant Sciences Inc, Alterras Therapeutics GmbH, United Therapeutics Corp, Chiesi Farmaceutici SpA, Gmax Biopharm LLC, Antlia Bioscience Inc, and others.
Hypertension Pipeline Analysis:
The Hypertension pipeline report provides insights into
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The report provides detailed insights about companies that are developing therapies for the treatment of Hypertension with aggregate therapies developed by each company for the same.
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It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Hypertension Treatment.
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Hypertension key companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
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Hypertension Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
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Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Hypertension market.
The report is built using data and information traced from the researcher’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc.
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Hypertension Pipeline Market Drivers
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Rising prevalence of Hypertension worldwide, robust Drug pipeline and the new product combinations are some of the important factors that are fueling the Hypertension Market.
Hypertension Pipeline Market Barriers
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However, high cost associated with the treatment of Hypertension, lack of awareness among people in developing countries and other factors are creating obstacles in the Hypertension Market growth.
Scope of Hypertension Pipeline Drug Insight
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Coverage: Global
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Key Hypertension Companies: Addpharma Inc., Alnylam Therapeutics, ORPHAI THERAPEUTICS, 35Pharma Inc., Aerovate Therapeutics, Novartis, Keros Therapeutics, Vigonvita Life Sciences, Insmed Incorporated, Chugai Pharmaceutical, Merck Sharp & Dohme, Janssen Pharmaceutical, Actelion, Gossamer Bio, Lung Biotechnology PBC, United Therapeutics, Gilead Science, Acceleron Pharma, Eiger BioPharmaceuticals, AstraZeneca, and others
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Key Hypertension Therapies: AD-209, Zilebesiran, LAM-001, HS135, AV-101, LTP001, KER-012, TPN171H, Treprostinil Palmitil, Satralizumab (Genetical Recombination), Sotatercept, Macitentan, ACT-293987, GB002 (seralutinib), Parenteral Treprostinil, Ralinepag, Selonsertib, Sotatercept, ubenimex, Olaparib, and others
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Hypertension Therapeutic Assessment: Hypertension current marketed and Hypertension emerging therapies
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Hypertension Market Dynamics: Hypertension market drivers and Hypertension market barriers
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Table of Contents
1. Hypertension Report Introduction
2. Hypertension Executive Summary
3. Hypertension Overview
4. Hypertension- Analytical Perspective In-depth Commercial Assessment
5. Hypertension Pipeline Therapeutics
6. Hypertension Late Stage Products (Phase II/III)
7. Hypertension Mid Stage Products (Phase II)
8. Hypertension Early Stage Products (Phase I)
9. Hypertension Preclinical Stage Products
10. Hypertension Therapeutics Assessment
11. Hypertension Inactive Products
12. Company-University Collaborations (Licensing/Partnering) Analysis
13. Hypertension Key Companies
14. Hypertension Key Products
15. Hypertension Unmet Needs
16 . Hypertension Market Drivers and Barriers
17. Hypertension Future Perspectives and Conclusion
18. Hypertension Analyst Views
19. Appendix
20. About DelveInsight
About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate business growth and overcome challenges with a practical approach.
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