DelveInsight’s “ESCLC Pipeline Insight, 2025” report provides comprehensive insights about 25+ companies and 30+ pipeline drugs in the ESCLC pipeline landscape. It covers the ESCLC pipeline drug profiles, including clinical and nonclinical stage products. It also covers the ESCLC pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Discover the latest drugs and treatment options in the ESCLC Pipeline. Dive into DelveInsight's comprehensive report today! @ ESCLC Pipeline Outlook
Key Takeaways from the ESCLC Pipeline Report
- On 08 October 2025, Bristol-Myers Squibb conducted a study is to demonstrate that treatment with BMS-986012 in combination with carboplatin, etoposide, and nivolumab will have acceptable safety and tolerability and will improve progression-free survival compared with carboplatin, etoposide, and nivolumab alone in newly diagnosed participants with ESCLC (ES-SCLC).
- On 08 October 2025, Novartis Pharmaceuticals organized a study aims to establish a safe and well tolerated dose of [177Lu]Lu-DOTA-TATE in combination with carboplatin, etoposide and atezolizumab in this setting and to assess the preliminary efficacy of this combination treatment versus the combination of carboplatin, etoposide, and atezolizumab. The study will be essential to assess a new potential therapeutic option in participants with this aggressive cancer type.
- On 07 October 2025, Merck Sharp & Dohme LLC initiated a study will consist of two parts. Part 1 will assess the safety, tolerability, and efficacy of gocatamig and I-DXd at doses determined in study MK-6070-001 (NCT: NCT04471727). Part 2 will assess the safety and tolerability of gocatamig in participants in Japan and China. Part 3 will assess the safety, tolerability, and efficacy of gocatamig with durvalumab.
- DelveInsight’s Extensive Stage Small Cell Lung Cancer pipeline report depicts a robust space with 25+ ESCLC companies working to develop 30+ pipeline therapies for Extensive Stage Small Cell Lung Cancer treatment.
- The leading Extensive Stage Small Cell Lung Cancer Companies such as Eli Lilly and Company, Genentech, Bristol-Myers Squibb, Henlix Biotech, CSPC ZhongQi Pharmaceutical Technology Co., Ltd., BioNTech SE, Xencor, Inc., Haihe Biopharma Co., Ltd., aizhou HoudeAoke Biomedical Co., Ltd., Celgene, MedImmune, Xcovery Holding Company LLC, Lee's Pharmaceutical Limited, Merck & Co, Astex Pharmaceuticals, and others.
- Promising Extensive Stages Small Cell Lung Cancer Pipeline Therapies such as Ifinatamab Deruxtecan (I-DXd), Trilaciclib, Obatoclax, Carboplatin/etoposide, and others.
Stay ahead with the most recent pipeline outlook for ESCLC. Get insights into clinical trials, emerging therapies, and leading companies with DelveInsight @ ESCLC Treatment Drugs
The ESCLC Pipeline Report provides disease overview, pipeline scenario and therapeutic assessment of the key pipeline therapies in this domain. The ESCLC Pipeline Report also highlights the unmet needs with respect to the ESCLC.
ESCLC Overview
Extensive-Stage Small Cell Lung Cancer (ESCLC) is a rapidly progressing form of lung cancer characterized by its aggressive nature and tendency to spread early to distant parts of the body. Unlike non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC) accounts for approximately 10-15% of all lung cancers and is strongly associated with smoking. In ESCLC, the cancer has spread beyond the hemithorax and regional lymph nodes, often involving the liver, bone marrow, brain, and adrenal glands. Patients with ESCLC often present with nonspecific symptoms that can include a persistent cough, chest pain, shortness of breath, and hemoptysis (coughing up blood). Due to its extensive nature, systemic symptoms such as weight loss, fatigue, and loss of appetite are common. Paraneoplastic syndromes, which are disorders triggered by an immune response to the cancer, can also occur, leading to conditions such as SIADH (syndrome of inappropriate antidiuretic hormone secretion), Cushing's syndrome, or Lambert-Eaton myasthenic syndrome.
ESCLC Emerging Drugs Profile
- Serplulimab+Chemo: Shanghai Henlius Biotech
Serplulimab (anti-PD-1 mAb) in combination with chemotherapy can be used for the treatment of ESCC, ES-SCLC, and GC. The Phase III clinical studies of Serplulimab in combination with chemotherapy for the treatment of Neo/adj. GC and LS-SCLC are on the fast track. Phase III clinical studies for sqNSCLC, ES-SCLC and LS-SCLC are global multi-centre trials. Currently, the drug is in Phase III stage of its development for the treatment of Extensive-Stage Small Cell Lung Cancer (ESCLC).
- Vobramitamab duocarmazine (MGC018): MacroGenics, Inc.
Vobramitamab duocarmazine (MGC018) is an investigational antibody-drug conjugate (ADC) comprised of a humanized B7-H3 monoclonal antibody (mAb) conjugated via a cleavable linker to the prodrug seco-DUocarmycin hydroxyBenzamide Azaindole (DUBA; licensed from Byondis, B.V.), with an average drug-to-antibody ratio (DAR) of ~2.7. DUBA is an alkylating agent that can damage DNA in both dividing and non-dividing cells, causing cell death. Vobra duo is designed to target solid tumors expressing B7-H3. Currently, the drug is in Phase II stage of its development for the treatment of Extensive-Stage Small Cell Lung Cancer (ESCLC).
- RYZ101: RayzeBio, Inc.
RYZ101 is an investigational targeted radiopharmaceutical therapy, designed to deliver a highly potent radioisotope, Actinium-225 (Ac225), to tumors expressing the somatostatin receptor type 2 (SSTR2). RYZ101 is being evaluated in clinical studies for patients with SSTR+ gastroenteropancreatic neuroendocrine tumors who have previously been treated with Lu177-based somatostatin therapies and also in patients with extensive stage small cell lung cancer. RYZ101 is being combined with current standard of care therapy. Currently, the drug is in Phase I stage of its development for the treatment of of Extensive-Stage Small Cell Lung Cancer (ESCLC).
If you’re tracking ongoing ESCLC Clinical trials, this press release is a must-read. Tap to see the breakthroughs @ ESCLC Treatment Drugs
The ESCLC Pipeline Report Provides Insights into
- The report provides detailed insights about companies that are developing therapies for the treatment of ESCLC with aggregate therapies developed by each company for the same.
- It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for ESCLC Treatment.
- ESCLC Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
- ESCLC Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
- Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the ESCLC market
ESCLC Companies
Eli Lilly and Company, Genentech, Bristol-Myers Squibb, Henlix Biotech, CSPC ZhongQi Pharmaceutical Technology Co., Ltd., BioNTech SE, Xencor, Inc., Haihe Biopharma Co., Ltd., aizhou HoudeAoke Biomedical Co., Ltd., Celgene, MedImmune, Xcovery Holding Company LLC, Lee's Pharmaceutical Limited, Merck & Co, Astex Pharmaceuticals, and others.
Extensive Stage Small Cell Lung Cancer (ESCLC) pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
- Oral
- Intravenous
- Subcutaneous
- Parenteral
- Topical
ESCLC Products have been categorized under various Molecule types such as
- Recombinant fusion proteins
- Small molecule
- Monoclonal antibody
- Peptide
- Polymer
- Gene therapy
Unveil the future of ESCLC Treatment. Learn about new drugs, pipeline developments, and key companies with DelveInsight's expert analysis @ ESCLC Market Drivers and Barriers
Scope of the ESCLC Pipeline Report
- Coverage- Global
- ESCLC Companies- Eli Lilly and Company, Genentech, Bristol-Myers Squibb, Henlix Biotech, CSPC ZhongQi Pharmaceutical Technology Co., Ltd., BioNTech SE, Xencor, Inc., Haihe Biopharma Co., Ltd., aizhou HoudeAoke Biomedical Co., Ltd., Celgene, MedImmune, Xcovery Holding Company LLC, Lee's Pharmaceutical Limited, Merck & Co, Astex Pharmaceuticals, and others.
- Extensive Stages Small Cell Lung Cancer Pipeline Therapies- Ifinatamab Deruxtecan (I-DXd), Trilaciclib, Obatoclax, Carboplatin/etoposide, and others
- ESCLC Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
- ESCLC Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
Get the latest on ESCLC Therapies and clinical trials. Download DelveInsight's in-depth pipeline report today! @ ESCLC Companies, Key Products and Unmet Needs
Table of Contents
- Introduction
- Executive Summary
- Extensive Stage Small Cell Lung Cancer (ESCLC): Overview
- Pipeline Therapeutics
- Therapeutic Assessment
- Extensive-Stage Small Cell Lung Cancer (ESCLC) – DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Serplulimab+Chemo: Shanghai Henlius Biotech
- Drug profiles in the detailed report…..
- Mid-Stage Products (Phase II)
- Vobramitamab duocarmazine (MGC018): MacroGenics, Inc.
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- RYZ101: RayzeBio, Inc.
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Drug Name: Company Name
- Drug profiles in the detailed report…..
- Inactive Products
- Extensive Stage Small Cell Lung Cancer (ESCLC) Key Companies
- Extensive Stage Small Cell Lung Cancer (ESCLC) Key Products
- Extensive Stage Small Cell Lung Cancer (ESCLC)- Unmet Needs
- Extensive Stage Small Cell Lung Cancer (ESCLC)- Market Drivers and Barriers
- Extensive Stage Small Cell Lung Cancer (ESCLC)- Future Perspectives and Conclusion
- Extensive Stage Small Cell Lung Cancer (ESCLC) Analyst Views
- Extensive Stage Small Cell Lung Cancer (ESCLC) Key Companies
- Appendix
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